Pancrageno 20 mg (Biorregulador)

Pancragen is a naturally occurring tetrapeptide bioregulator that, as the name implies, has primary effects on the pancreas. Not to be confused with the DNA-based PancraGEN test, Pancragen has been shown to help control blood sugar, improve endocrine function of the pancreas, regulate melatonin expression, and reduce the incidence and magnitude of metabolic syndrome. It has been investigated and is of interest in the treatment of both diabetes and the metabolic effects of aging. To some extent, Pancragen can be thought of as an anti-aging peptide for the pancreas.

Secuencia de aminoácidos: Lys-Glu-Asp-Trp (KEDW)
Fórmula molecular: C₂₆h₃₆norte₆oh₉
Peso molecular: 576.25 g/mol
PubChem CID: 68452887
Sinónimos: ESQUEMABL5491754

Fuente: PepDraw

Research on pancreatic cells shows that Pancragen stimulates the expression of a number of differentiation factors that control the growth of acinar and islet of Langerhans cells. The latter are responsible for insulin and glucagon[1]. Though this may not seem like an anti-aging effect, it should b clear that restoration of improved growth and differentiation is a feature of young, healthy tissues. Improving these parameters, particularly in older tissues, is fundamentally an anti-aging effect. Throughout the rest of the sections of Pancragen, additional reasons for its classification as an anti-aging peptide will be manifest. En particular, its ability to change the epigenetic regulation of DNA to improve gene expression is one of the clearest indications that Pancragen can turn back the clock on DNA to promote function more in keeping with youth.

Pancragen and Metabolic Disorders

Further supporting the idea that Pancragen is an anti-aging peptide are its effects on metabolic disorders. Research shows that metabolic dysregulation in older people is at least partially caused by changes in melatonin secretion during sleep. This melatonin deficiency appears to be caused by changes in insulin levels, suggesting that loss of insulin function, both in disease and as a result of old age, may be responsible for changes in melatonin secretion, which is then responsible for some of the other symptoms of metabolic syndrome[2].

Based on the above line of thought, it stands to reason that administration of Pancragen, which helps to normalize insulin secretion, could further reduce symptoms of metabolic syndrome by normalizing melatonin secretion. De hecho, this is precisely what research reveals. Administration of Pancragen decreases glucose levels but also reduces plasma concentrations of insulin as well as the insulin resistance index which are strong indications that Pancragen is having a direct effect on melatonin signaling[2].

Both exogenous and endogenous melatonin inhibit the pathophysiological mechanisms of metabolic syndrome and normalize metabolism[3]. Research shows that melatonin receptors exist in the pancrease where they serve to modulate insulin and glucagon signaling in a diurnal (daylight-sensitive) fashion[4]. There is a lot of new research focusing on how disruptions in melatonin signaling are linked to the development of type 2 diabetes and metabolic syndrome.

If melatonin affects the pancreas, then is stands to reason that there is likely a feedback mechanism by which glucagon and insulin signal to the pineal gland whether to increase or decrease melatonin release. De hecho, this feedback loop exists and, in type 2 diabetes, appears to be responsible for the additional metabolic effects that arise in this version of the disease that are less common in type 1 diabetes. This would explain why Pancragen’s ability to regulate insulin secretion of the pancreas also has beneficial effects on other symptoms of metabolic syndrome.

Fuente: PubChem

Pancragen and Diabetes

Por supuesto, the most obvious use for Pancragen is in the treatment of diabetes, hyperinsulinemia, and elevated blood glucose levels. Research in rhesus monkeys comparing Pancragen to glimepiride (a widely used drug for lowering blood sugar) reveals that while both compounds can reduce blood sugar levels to normal baselines, only Pancragen normalizes insulin levels and C-peptide levels[5], [6]. This would suggest that Pancragen is having a more physiologic effect, striking at the very heart of what causes elevated blood sugar and correcting the problem at a more fundamental level.

Research in old monkeys shows that Pancragen normalizes plasma insulin, C-peptide, and glucose levels within 10 days and that the effect lasts, al menos parcialmente, for as long as 3 semanas[7], [8]. This suggests that Pancragen might be useful in restoring pancreatic function in elderly individuals or maintaining it as we age. This can help to normalize the metabolic system and reduce the impact of everything from osteoporosis to dementia.

Additional research in cell cultures shows that Pancragen increases the expression of matrix metalloproteinases MMP2 and MMP9. It also increases the expression of serotonin, glycoprotein CD79alpha, and the anti-apoptotic protein MCl1 while decreasing levels of the pro-apoptotic protein p53. Además, levels of proliferation markers PCNA and Ki67 are increased. Vasili Ashapkin, author of the textbook DNA Methylation in Plants and collaborator with Vladimir Khavinson, points out that these findings collectively indicate that Pancragen activates the expression of signaling molecules associated with increased differentiation and functionality of pancreatic islet cells[9], [10]. These effects can only be accounted for by a broad functional mechanism such as direct alteration of DNA expression and condensation patterns. En otras palabras, Pancragen is likely working at a very fundamental level within the DNA to alter the expression of multiple genes.

Pancragen and the Vascular System

One of the most serious consequences of diabetes is on the function of small blood vessels called capillaries. Elevated glucose levels cause these capillaries to first become leak and then to die off as the cells that make them up, called endothelial cells, become dysfunctional and then die. Many of the long-term consequences of diabetes like heart disease, nefropatía, erectile dysfunction, and loss of limb result from damage to and loss of capillaries.

Research on Pancragen shows that it helps to normalize the adhesion of mesenteric capillary endothelium[11]. These findings suggest that Pancragen could protect the endothelium from some of the effects of diabetes, thus helping to stave off long-term consequences of the disease.

Pancragen and the Vascular System

One of the most serious consequences of diabetes is on the function of small blood vessels called capillaries. Elevated glucose levels cause these capillaries to first become leak and then to die off as the cells that make them up, called endothelial cells, become dysfunctional and then die. Many of the long-term consequences of diabetes like heart disease, nefropatía, erectile dysfunction, and loss of limb result from damage to and loss of capillaries.

La literatura anterior fue investigada, editado y organizado por el Dr.. mi. logan, MARYLAND. Dr. mi. Logan tiene un doctorado de Facultad de Medicina de la Universidad Case Western Reserve y una licenciatura. en biología molecular.

Vladimir Khavinson es un profesor, Presidente de la región europea de la Asociación Internacional de Gerontología y Geriatría; Miembro de Academias de Ciencias Médicas de Rusia y Ucrania; Gerontólogo principal del Comité de Salud del Gobierno de San Petersburgo, Rusia; Director del Instituto de Biorregulación y Gerontología de San Petersburgo; Vicepresidente de la Sociedad Gerontológica de la Academia Rusa de Ciencias; Jefe de la Cátedra de Gerontología y Geriatría de la Universidad Médica Estatal del Noroeste, San Petersburgo; coronel del servicio médico (URSS, Rusia), jubilado. Vladimir Khavinson es conocido por el descubrimiento., estudios experimentales y clínicos de nuevas clases de péptido biorreguladores, así como para el desarrollo de terapias con péptidos biorreguladores.. Se dedica al estudio del papel de los péptidos en la regulación de los mecanismos del envejecimiento.. Su principal campo de actuación es el diseño., Estudios preclínicos y clínicos de nuevos péptidos. geroprotectores. Una investigación de 40 años dio como resultado una multitud de métodos de aplicación de biorreguladores peptídicos para ralentizar el proceso de envejecimiento y aumentar la esperanza de vida humana.. Seis productos farmacéuticos basados ​​en péptidos y 64 Los complementos alimenticios peptídicos han sido introducidos en la práctica clínica por V.. Khavinson. Es autor de 196 patentes (ruso e internacional) así como de 775 publicaciones cientificas. Sus principales logros se presentan en dos libros.: “Péptidos y envejecimiento” (EN EL, 2002) y "Aspectos gerontológicos de la regulación de péptidos del genoma" (Karger AG, 2005). Vladimir Khavinson presentó la especialidad científica. “Gerontología y Geriatría” en la Federación de Rusia a nivel gubernamental. Consejo Académico encabezado por V. Khavinson ha supervisado 200 Doctor. y tesis doctorales de muchos países diferentes.

Profe. Vladimir Khavinson is being referenced as one of the leading scientists involved in the research and development of Pancragen. De ninguna manera este médico/científico respalda o defiende la compra, venta, o uso de este producto por cualquier motivo. No hay afiliación o relación., implícito o no, entre

1. V. k. Khavinson et al., “Effects of pancragen on the differentiation of pancreatic cells during their ageing," Toro. Exp. biol. Con., volumen. 154, No. 4, páginas. 501–504, Feb. 2013, doi: 10.1007/s10517-013-1987-6.
2. oh. V. Korkushko, V. k. Khavinson, V. B. Shatilo, I. A. Antonyk-Sheglova, y E. V. Bondarenko, “Prospects of using pancragen for correction of metabolic disorders in elderly people," Toro. Exp. biol. Con., volumen. 151, No. 4, páginas. 454–456, Ago. 2011, doi: 10.1007/s10517-011-1354-4.
3. S. I. Rapoport, A. I. Molchanov, V. A. Golichenkov, oh. V. Burlakova, mi. S. Suprunenko, y E. S. Savchenko, “[Metabolic syndrome and melatonin]," Cuña. Con. (Moscú.), volumen. 91, No. 11, páginas. 8–14, 2013.
4. mi. Peschke, I. Bähr, y E. Mühlbauer, “Melatonin and pancreatic islets: interrelationships between melatonin, insulin and glucagon," En t. j. Mol. ciencia., volumen. 14, No. 4, páginas. 6981–7015, Mar. 2013, doi: 10.3390/ijms14046981.
5. norte. D. Goncharova, l. GRAMO. Ivanova, t. mi. Oganyan, A. A. Vengerin, y V. k. Khavinson, “[Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys]," Avanzado. gerontol. Uspekhi Gerontol., volumen. 28, No. 3, páginas. 579–585, 2015.
6. V. k. Khavinson, METRO. M.-G. Gapparov, norte. mi. Sharanova, A. V. Vasilyev, y G. A. ryzhak, “Study of biological activity of Lys-Glu-Asp-Trp-NH2 endogenous tetrapeptide," Toro. Exp. biol. Con., volumen. 149, No. 3, páginas. 351–353, Sep. 2010, doi: 10.1007/s10517-010-0944-x.
7. norte. D. Goncharova, l. GRAMO. Ivanova, t. É. Oganian, A. A. Vengerin, y V. k. Khavinson, “[Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys]," Avanzado. gerontol. Uspekhi Gerontol., volumen. 27, No. 4, páginas. 662–667, 2014.
8. I. METRO. Kvetnoi, A. PAG. ryzhak, I. norte. Kostyuchek, y Y. A. Tafeev, “Effect of tetrapeptide pancragene on functional morphology of the pancreas in rats with experimental diabetes mellitus," Toro. Exp. biol. Con., volumen. 143, No. 3, páginas. 368–371, Mar. 2007, doi: 10.1007/s10517-007-0114-y.
9. V. k. Khavinson et al., “[Tetrapeptide stimulates functional activity of the pancreatic cells in aging]," Avanzado. gerontol. Uspekhi Gerontol., volumen. 25, No. 4, páginas. 680–684, 2012.
10. V. V. Ashapkin, norte. S. Linkova, V. k. Khavinson, y B. F. vanyushin, “Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells," bioquímica. Bioquímica, volumen. 80, No. 3, páginas. 310–322, Mar. 2015, doi: 10.1134/S0006297915030062.
11. V. k. Khavinson, norte. A. Gavrisheva, V. V. de Malí, S. GRAMO. Chefu, y E. l. Trofimov, “Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus," Toro. Exp. biol. Con., volumen. 144, No. 4, páginas. 559–562, Oct. 2007, doi: 10.1007/s10517-007-0377-3.

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