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GHRP-2 представляет собой синтетический стимулятор секреции гормона роста, который связывается с рецептором, стимулирующим секрецию грелина/гормона роста. Исследования показали, что он улучшает рост мышц, регулирует иммунную систему и улучшает циклы сна. Исследования GHRP-2 показали, что он обладает биологической активностью при пероральном приеме.
Использование продукта:Этот ПРОДУКТ ПРЕДНАЗНАЧЕН ТОЛЬКО КАК ИССЛЕДОВАТЕЛЬСКИЙ ХИМИКАТ.Это обозначение позволяет использовать исследовательские химикаты исключительно для испытаний in vitro и лабораторных экспериментов. Вся информация о продуктах, доступная на этом сайте, предназначена только для образовательных целей. Любое телесное введение людям или животным строго запрещено законом. С этим продуктом должны работать только лицензированные и квалифицированные специалисты. Этот продукт не является лекарством, продуктом питания или косметическим средством, и его нельзя маркировать, использовать или маркировать как лекарство, продукт питания или косметику.
GHRP-2 (также известный как пралморелин) представляет собой синтетический стимулятор секреции гормона роста, который, как известно, связывается с рецептором стимулятора секреции грелина/гормона роста. Это был первый из представленных на рынке средств, стимулирующих секрецию гормона роста, и в настоящее время он продается как тестовый пептид для оценки дефицита гормона роста и вторичной недостаточности надпочечников. GHRP-2 исследовался на стадии II клинических испытаний для оценки низкого роста и активно исследуется его влияние на аппетит, рост мышц, иммунную систему и циклы сна. GHRP-2 активен при пероральном и сублингвальном приеме, поэтому для достижения эффекта его не обязательно вводить.
Источник:PubChem
Последовательность:Д-Ала-Д-2Нал-Ала-Трп-Д-Фе-Лис
Молекулярная формула:С45ЧАС55Н9О6
Молекулярный вес:817,9749 г/моль
Идентификатор клиента PubChem: 6918245
Номер КАС:158861-67-7
Кодовые имена:КП-102, ГПА-748, ПУТЬ-ГПА-748
Исследования на яках показывают, что GHRP-2 может стимулировать рост мышц двумя способами: увеличением отложения белка и уменьшением его деградации. Исследование показало, что GHRP-2 может преодолевать естественные плато роста, возникающие у яков из-за нехватки пищи, болезней и неблагоприятных условий окружающей среды (например, холода).[1]. The most profound finding from this study is that GHRP-2 reduces muscle atrophy by inactivating atrogin-1 and MuRF1, proteins that control the muscle degradation pathway[2]. There is hope that these findings could be used to reduce the catabolism common in chronic illnesses like autoimmune disease, cancer, and more.
Of course, by activating growth hormone and insulin-like growth factor-1, GHRP-2 helps to boost muscle protein deposition. The combined effect of reducing degradation and enhancing deposition is that GHRP-2 encourages the development of lean body mass even in adverse conditions[3].
GHRP-2 has been shown to boost food intake[4], [5]. Though this may not seem acutely important, appetite stimulation in the setting of chronic disease is an important part of overall health care. The ability to easily and reliably stimulate appetite could help doctors treat chronically ill patients and improve long-term outcomes.
Food intake in healthy adult men, placebo versus GHRP-2
Source: PubMed
Research in fetal heart cell culture lines shows that GHRP-2 and its analogues (GHRP-1 and GHRP-6) can help to protect heart cells by reducing apoptosis or programmed cell death[6]. This is of particular importance following heart attack, when heart cells are particularly prone to apoptosis thanks to decreased blood and thus nutrient supply. Research using an analogue of GHRP-2 called Hexarelin has indicated that there may be a specific receptor for these peptides[7]. Identifying new receptors in any tissue opens pathways for new drug development, but also deepens our understanding of the human physiology and how to prevent dysfunction in the first place.
GHRP-2 has been shown to stimulate the thymus, an organ responsible for protecting certain cells of the immune system. In particular., the thymus helps T cells to mature. T cells are critical for adaptive immunity and our ability to fight off complex infections. Function of the thymus declines with age, which leads to a number of age-related dysfunctions ranging from inadequate tissue repair to lost immunity and thus an inability to fight off infections, guard against cancer, and maintain normal tissue function. GHRP-2 has been shown to rejuvenate the thymus, boosting the number and diversity of T-cells it produces[8]. This leads to improved immunity.
Change in number of active T-cells following administration of GHRP-2
Source: PubMed
GHRP-2 has been shown to increase the duration stages 3 and 4 of the sleep cycles by about 50% each while increasing REM sleep by approximately 20% while reducing the amount that an individual deviates from “normal sleep” by as much as a third. Overall, the improvement in sleep led to improvement in cognitive function, blood pressure, healing, and energy levels[9]. These findings, while useful to all adults, are particularly important in the elderly, where the effects of aging take a toll on sleep quality. GHRP-2 may be useful in understanding how to fine-tune sleep to improve quality and maybe even help people get all the benefits of a full night’s sleep in a fraction of the time.
It was originally thought that observations of decreased pain in animal models of osteoarthritis were the result of GHRP-2 boosting growth hormone levels and accelerating healing in the damaged tissues. Keen scientists observed, however, that the pain relief preceded healing by a substantial margin, suggesting that GHRP-2 may have direct effects on pain perception. As it turns out, GHRP-2 has action at the opioid receptors[10].
There are four known opioid receptors. Most opioid pain medications do not discriminate between them. This is problematic because while some of the receptors mediate pain, others affect things like wakefulness and breathing while still others impact addiction. GHRP-2 is a selective opioid receptor agonist, binding primarily to the receptors responsible for pain relief, sedation, and addiction. This finding indicates that it may be possible to produce selective opioid agonists and therefore mitigate or prevent entirely undesirable effects like respiratory depression and addiction.
GHRP-2 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. GHRP-2 for sale at
The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.
Jean-Alain Fehrentz was born in Nancy, France, in 1955. He received his Ph.D. degree in Chemistry from the University of Nancy in 1983 and joined the Centre CNRS-INSERM de Pharmacologie Endocrinologie of Montpellier in the research group of Professor B. Castro. From 1989 to 1992 he was appointed as researcher at Sanofi Research in Montpellier. Then he moved to the Faculty of Pharmacy of Montpellier, working under the direction of Professor J. Martinez. His research interests focus onpeptide aldehydes, enzyme inhibitors, peptidomimetics, growth hormone interactions, and heterocycle based receptor ligands. He has published more than 150 scientific papers.
Jean-Alain Fehrentz is being referenced as one of the leading scientists involved in the research and development of GHRP-2. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between
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