Grátis (1) 30 ml de água bacteriostática
com ordens qualificadas sobreUS $ 500 USD.
(Exclui produtos de cápsula, peptídeos cosméticos, códigos promocionais e remessa)
GHK-CIé um peptídeo natural no plasma sanguíneo humano, urina e saliva. A pesquisa em animais revela que o GHK-Cu pode melhorar a cicatrização de feridas, a função imunológica e a saúde da pele, estimulando o colágeno, os fibroblastos e promovendo o crescimento dos vasos sanguíneos. Houve evidências que mostraram que ele atua como um sinal de feedback que é gerado após lesão no tecido. Também suprime dano ao radical livre e, portanto, é um potente antioxidante.
Uso do produto:Este produto é destinado apenas a um produto químico de pesquisa.Essa designação permite o uso de produtos químicos de pesquisa estritamente para testes in vitro e apenas experimentação laboratorial. Todas as informações do produto disponíveis neste site são apenas para fins educacionais. A introdução corporal de qualquer tipo em seres humanos ou animais é estritamente proibida por lei. Este produto deve ser tratado apenas por profissionais qualificados e licenciados. Este produto não é um medicamento, alimento ou cosmético e pode não ser de marca mal, mal utilizada ou incorreta como droga, comida ou cosmético.
GHK-Cu é um peptídeo que ocorre naturalmente primeiro isolado do plasma sanguíneo humano. Desde então, também foi identificado na urina e na saliva. Pesquisas sobre GHK-Cu descobriram que o peptídeo curto tem benefícios substanciais na cicatrização de feridas e função imunológica. Possui propriedades antienvelhecimento e foi encontrado para suprimir danos ao radical livre, aumentar a síntese de proteínas, combater bactérias e aumentar a saúde da pele e dos fibroblastos da pele.
Sequência:Gly-his-lys.cu.xhac
Fórmula Molecular:C14H23CUN6O4
Peso molecular:340.384 g/mol
Pubchem CID: 73587
Número CAS:89030-95-5
O GHK-Cu é uma parte natural do sangue humano e, como tal, foi encontrado para desempenhar um papel integral nas vias de regeneração da pele. Pesquisas em culturas de pele descobriram que o GHK estimula a síntese e a quebra do colágeno, glicosaminoglicanos e outros componentes da matriz extracelular, como proteoglicanos e sulfato de condroitina. Pelo menos parte desse efeito é mediada pelos benefícios positivos de recrutamento que o GHK-Cu tem nos fibroblastos, células imunes e células endoteliais. O peptídeo atrai essas células para o local da lesão e parece coordenar sua atividade na reparação dos danos[1].
GHK-Cu is a common component of skin-care and cosmetic products. It improves elasticity of the skin while tightening and firming. It has also been shown to reduce damage due to sunlight, reduce hyperpigmentation, and reduce the appearance of fine lines and wrinkles[1]. The ability of GHK-Cu to modulate collagen synthesis is important in reducing the appearance of scars, preventing hypertrophic healing from taking place, smoothing rough skin, and repair the structure of aged skin. These roles of GHK-Cu are mediated partly though its ability to boost levels of transforming growth factor-Β[2]. It is likely that the peptide works through several different biochemical pathways and that it has effects and the level of gene transcription[3].
Research in mice shows that GHK-Cu increases the rate of healing following burn by as much as 33%. It appears that besides recruiting immune cells and fibroblasts to the site of injury, GHK-Cu also encourages the growth of blood vessels[4]. Burned skin is often slow to regrow blood vessels due the cauterization effect, so these findings open up a new pathway for improving wound care in burn units and accelerating healing.
The invasion of tissue by foreign pathogens is one of the primary reasons that wounds are slow to heal or do not heal at all. Bacterial and fungal infections are particularly problematic in burn patients and in those with compromised immune systems (e.g. diabetes, HIV). GHK-Cu, when combined with certain fatty acids, creates a potent antimicrobial compound that is active against a number of bacteria and fungi known to complicate wound healing[5].
Research in diabetic patients has shown that GHK-Cu is superior to standard care regimens alone in the treatment of diabetic ulcers. Patients given both standard care and GHK-Cu showed a ~40% increase in wound closure and a 27% decrease in rates of infection compared to control groups[6]. Similar results were seen in patients with ischemic open wounds[7].
The death of neurons due to degenerative diseases like Alzheimer’s is poorly understood. This makes it difficult to develop treatments and those that are available are generally of limited efficacy. Research, however, suggests that GHK-Cu can counter the age-associated decline in neuron function that often underlies these diseases. Research shows that GHK-Cu can improve angiogenesis in the nervous system, boost nerve outgrowth, and reduce inflammation in the central nervous system. There is even evidence that GHK-Cu can reset pathological gene expression and help to recreate a state of health in dysfunctional systems[8].
GHK-Cu is found in high concentrations in the brain, though levels of the peptide decline with age. There is a thought, among scientists, that GHK-Cu may protect nervous system tissues against natural insults such as gene dysregulation and that it is the decline in GHK-Cu with age, and not the onset of new disease processes, that actually leads to neurodegeneration.
GHK-Cu Levels in various tissues
Source: PubMed
Research in rats indicates that one possible mechanism by which GHK-Cu protects brain tissue is by preventing apoptosis. This action appears to be mediated through the well-known miR-339-59/VEGFA pathway, which is active following brain bleeds and stroke. In the rat models, GHK-Cu improves neurological deficits in the brain, reduce swelling, and inhibited the death of neurons that is commonly bought about by overexpression of miR-339-5p[9].
Research in mice shows that GHK-Cu can protect the lungs against fibrosis that occurs following therapy with the cancer drug bleomycin[10]. This could pave the way for using GHK-Cu as a chemotherapy adjuvant that allows doses of these life-saving medications to be increased without risk of increased side effects. The study when a step farther, than usual, by identifying the likely pathway by which GHKC-Cu protects against fibrosis. It appears that the peptide regulations TNF-alpha dn IL-6 levels, both of which act as inflammatory molecules and affect the extracellular matrix and smooth muscle of the lung. By reducing inflammation in the lungs, GHK-Cu prevents fibrotic remodeling from taking place and improves collagen deposition.
Similar benefit of GHK-Cu in protecting lungs was found in mouse models of acute respiratory distress syndrome (ARDS), an inflammatory lung condition that can develop rapidly and be fatal. ARDS is associated with injury, infection, and certain drugs like those used in chemotherapy. Once again, GHK-Cu appeared to mediate its effects through decreased TNF-alpha and IL-6 expression[11].
In rat models, the administration of GHK-Cu had a dose-dependent effect on pain-induced behavior. The peptide appears to have analgesic effects that are produced through increased levels of the natural painkiller L-lysine[12]. Similar research has found that the peptide can also increase levels of L-arginine, another analgesic amino acid[13]. These findings open up new avenues for pain control that do not rely on addictive opiate medications or NSAIDs, which have been found to have negative effects on the heart.
GHK-Cu exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. GHK-Cu for sale at
The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.
Loren Pickart, Ph.D. has released 109 publications and is developing patents and analyzing GHK’s effects on human gene expression of 4,192 genes. In addition to GHK’s published potential uses on skin inflammation, metastatic cancer and COPD, it appears to have beneficial effects on other tissue systems such as the nervous system, gastrointestinal system, and mitochondrial system. His brief but detailed autobiography dives into the motivations and background behind his dedicating to skin, anti-aging, and life-long training.
Loren Pickart, Ph.D is being referenced as one of the leading scientists involved in the research and development of GHK-Cu. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between
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