러시아에서 개발 된 셀 락스 (Selank)는 자전거 및 불안 완화 특성을 가진 짧은 펩티드입니다. IL-6, T 도우미 세포, 모노 아민 신경 전달 물질 및 뇌 유래 신경성 인자 (BDNF)를 조절하는 면역 조절 펩티드 인 자연적으로 발생하는 tuftsin의 합성 유사체이다. 실제로, Selank와 Tuftsin은 셀랑크가 체인에 4 개의 아미노산을 가지고있어 대사 안정성과 반감기를 향상시키는 데 도움이된다는 점을 제외하고는 본질적으로 동일합니다.

Selank는 일반화 불안 장애에 대한 잠재적 치료로 임상 시험에서 테스트되었습니다.

순서: thr-lys-pro-arg-pro-gly-pro
분자식: c₃₃시간₅₇N₁₁영형₉
분자량: 751.887 g/mol
Pubchem Cid: 11765600
CAS 번호: 129954-34-3
동의어: 셀랑

원천:Pubch

GABA Neurotransmitter와 관련된 유전자에 기초한 Selank 불안 효과

Anastasiya Volkova 박사에게 공인러시아의 분자 유전학 연구소“수많은 임상 연구에 따르면 Selank는 불안 치료에 강한 항발성 및 신경 보호 효과가 있음을 보여주었습니다. Selank의 임상 효과는 GABAA 수용체의 알로 스테 릭 조절제 인 Benzodiazepine과 같은 고전적인 항발 약물의 임상 효과와 유사합니다.” Selank의 영향에는 불안 감소, 기분 개선, 스트레스 수준 감소 및 기억과 학습에 긍정적 인 영향을 미칩니다. 벤조디아제핀과 마찬가지로 저용량의 셀랑크는 진정 효과가 있습니다. 벤조디아제핀과 달리 셀락은 습관성이없는 것으로 보이며 금단 또는 기억 상실 증상으로 이어지지 않습니다.

쥐의 연구에 따르면 어떤 식 으로든 GABA 신호 전달에 연결된 것으로 알려진 84 개의 유전자 중 7 개는 Selank에 의해 크게 조절되고 45 개는 펩티드를 투여 할 때 발현의 변화를 보여줍니다. 전반적으로 GABA 신호 전달과 관련된 52 개의 유전자가 Selank에 의해 어느 정도 영향을받습니다. 이러한 결과는 Selank가 신경 세포에서 유전자의 발현에 직접 영향을 줄 수 있으며 GABA에 대한 GABA 수용체의 친화력을 변화시켜 효과를 생성 할 수 있음을 나타냅니다.^[1]. This alteration of receptor affinity likely explains why Selank is synergistic with benzodiazepines and other GABA receptor agonists.

Changes in gene expression as a function of time in rats treated with Selank.
Source: PubMed

Research in rats shows that Selank and benzodiazepines, when used alone, have similar effects on anxiety, particularly generalized anxiety disorder. Selank may hold a slight advantage over benzodiazepines when attempting to reduce elevated levels of anxiety, but a combination of the two treatments appears to be the best in treating unpredictable chronic mild stress^[2].

The effects that Selank has on GABA receptors may be modulated, to some degree, by the peptide’s effect on enkephalin degradation. Testing indicates that people with anxiety and phobic disorders demonstrate increased enkephalinase activity in the blood during generalized anxiety and, as a result, the enkephalins they produce have shorter half-lives^[3]. By preventing degradation of enkephalins through enkephalinase inhibition, Selank may be resetting this enzymatic pathway and helping to protect the body’s natural anxiolytic peptides. Research in mice prone to anxiety supports the hypothesis that at least part of the impact that Selank has is a result of preventing enkephalin degradation^[4].

Selank and the Immune System in Anxiety

Research in patients with depression indicates that Selank can suppress the gene responsible for the production of the inflammatory cytokine IL-6. Interestingly, this effect is only seen in patients with depression and does not appear to take place in healthy individuals^[5]. This suggests that Selank may be useful in treating people with anxiety-asthenic disorders, severe disorders in which anxiety is associated with fatigue, headache, heart palpitations, high blood pressure, nerve pain, and depression.

When comparing Selank to standard anxiolytic treatments, like benzodiazepines, the two treatments show similar benefits in reducing anxiety, but only Selank has any effect on asthenic symptoms like fatigue and pain^[6]. Part of the effect is likely due to Selank’s ability to modulated IL-6 expression while part is likely due to the peptide’s ability to alter the rate of breakdown of the body’s natural pain killers, enkephalins.

Testing of Selank in rats has revealed that the peptide regulates the expression of some 34 genes involved in the inflammatory process. These genes affect chemokines, cytokines, and receptors for both. In particular, Selank has been found to alter expression of BcI6, a gene that is heavily involved in the development of the immune system^[7]. This study, more than any other, revealed that Selank has very complex biological effects, but may help to deepen our understanding of how the immune system develops.

Selank and even fragments of Selank have been shown to temporarily alter gene expression for C3, CAsp1, Il2rf, and Xcr1 in the mouse spleen. By affecting these genes, Selank is able to alter the balance of the immune system and thereby modulate inflammation^[8].

Selank Research with Memory and Learning

There has long been an association between anxiety and learning/memory. The correlation is a negative one, with increased anxiety leading to decreased ability to recall memories or store new information. Traditional anxiety treatments can reduce this effect, as can Selank, but Selank appears to do more than simply reduce the impact of anxiety on cognitive function. There is good reason to believe that Selank actually boosts cognition directly.

Research in rats trains with food rewards and injected with either saline or Selank has shown that Selank boosts memory trace stability and thus enhances the memory storage process^[9]. It is important to note that this benefit was seen regardless of the anxiety levels of the rats, indicating that the peptide has effects beyond its ability to simply reduce stress-related impairment of memory.

It appears that Selank may alter memory by affecting the expression of a number of genes in the hippocampus. Research in rats shows changes in mRNA levels of 36 different genes after intranasal administration of Selank. Most of the genes encode proteins associated with the plasma membrane and may therefore modulate ion-dependent processes in learning and memory^[10]. Though much research needs to be done to understand the mechanism by which Selank works to improve memory and learning, this research offers a tantalizing early clue to suggest that it alters the way neurons function in such a way that both forming and accessing memories is easier.

Research even suggests that Selank can help to rescue memory and learning following damage to the brain. Rats treated with a neurotoxin and then Selank showed restored cognitive processes in at least one study. This effect appears to be related to an artificial inhibition of the catecholamine system in the brain by Selank^[11]. There is some hope that Selank will help to shed light on how cognitive function can be restored or at least improved following traumatic brain injury, particularly the kinds of injury that occurring during the birth process.

Selank Research and Pain

Selank may act to reduce the degradation of natural enkephalins by inhibiting the enzymes, found in human blood, that break them down^[12]. Enkephalins are natural peptides that bind to opioid receptors and help to blunt the severity of pain. They also function in the human stress response and are found in high levels in the brain and adrenal glands. By reducing levels of enkephalins in the brain, Selank may help to blunt the normal stress response and the effects that it has on memory, learning, and concentration.

Selank exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Selank for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Selank if you are a licensed researcher.

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Dr. Petr Slominsky‘s 169 research works with 803 citations. 12 of those papers pertain to the examination of Selank’s diverse, multifaceted effects e.g. anxiety reduction, changes in the transcription profile of the hippocampus, and changes in expression of the genes for chemokines, cytokines, and their receptors. Dr. Slominsky is particularly interested in the epigenetic effects of Selank and other disease-state pathologies.

Dr. Petr Slominsky is being referenced as one of the leading scientists involved in the research and development of Selank. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Sciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Dr. Petr Slominsky is listed in [7] under the referenced citations.

1. A. Volkova et al., “Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission,” Front. Pharmacol., vol. 7, Feb. 2016. [PubMed]
2. A. Kasian et al., “Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats,” Behavioural Neurology, 2017. [Online]. Available: https://www.hindawi.com/journals/bn/2017/5091027/.
3. A. A. Zozulya et al., “The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity,” Bull. Exp. Biol. Med., vol. 131, no. 4, pp. 315–317, Apr. 2001. [PubMed]
4. O. Y. Sokolov, V. K. Meshavkin, N. V. Kost, and A. A. Zozulya, “Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions,” Bull. Exp. Biol. Med. [PubMed]
5. O. N. Uchakina et al., “[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders],” Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, vol. 108, no. 5, pp. 71–75, 2008. [PubMed]
6. A. A. Zozulia et al., “[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia],” Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova, vol. 108, no. 4, pp. 38–48, 2008. [PubMed]
7. T. Kolomin, M. Shadrina, L. Andreeva, P. Slominsky, S. Limborska, and N. Myasoedov, “Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank,” Regul. Pept., vol. 170, no. 1–3, pp. 18–23, Oct. 2011. [PubMed]
8. T. I. Agapova et al., “[Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex],” Mol. Genet. Mikrobiol. Virusol., no. 3, pp. 28–32, 2008. [PubMed]
9. T. P. Semenova, I. I. Kozlovskiĭ, N. M. Zakharova, and M. M. Kozlovskaia, “[Experimental optimization of learning and memory processes by selank],” Eksp. Klin. Farmakol., vol. 73, no. 8, pp. 2–5, Aug. 2010. [PubMed]
10. T. A. Kolomin et al., “[c],” Zh. Vyssh. Nerv. Deiat. Im. I. P. Pavlova, vol. 63, no. 3, pp. 365–374, Jun. 2013.
11. T. P. Semenova, M. M. Kozlovskaya, N. M. Zakharova, I. I. Kozlovskii, and A. V. Zuikov, “Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny,” Bull. Exp. Biol. Med., vol. 144, no. [PubMed]
12. N. V. Kost et al., “[Semax and selank inhibit the enkephalin-degrading enzymes from human serum]],” Bioorg. Khim., vol. 27, no. 3, pp. 180–183, Jun. 2001. [Springer]

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.