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GHRP-2는 그렐린/성장 호르몬 분비 대상 수용체에 결합하는 합성 성장 호르몬 분비물입니다. 근육 성장을 개선하고 면역계를 조절하며 수면주기를 개선하기위한 연구 시험에서 보여졌습니다. GHRP-2 연구에 따르면 경구 생물 활성이있는 것으로 나타났습니다.

제품 사용 :이 제품은 연구 화학 물질로만 의도 된 것입니다.이 명칭은 시험 관내 시험 및 실험실 실험에만 연구 화학 물질을 엄격하게 사용할 수있게한다. 이 웹 사이트에서 제공되는 모든 제품 정보는 교육 목적으로 만 사용됩니다. 인간이나 동물에 어떤 종류의 신체적으로 소개되는 것은 법에 의해 엄격히 금지되어 있습니다. 이 제품은 라이센스가 부여 된 자격을 갖춘 전문가 만 처리해야합니다. 이 제품은 약물, 음식 또는 화장품이 아니며 약물, 음식 또는 화장품으로 잘못 브랜드화되거나 잘못 사용되거나 오해가되지 않을 수 있습니다.

GHRP-2는 무엇입니까?

GHRP-2 (일명 Pralmorelin)는 그렐린/성장 호르몬 분비 대상 수용체에 결합하는 것으로 알려진 합성 성장 호르몬 분비물입니다. 그것은 성장 호르몬 분비자가 처음으로 도입되었으며 현재 성장 호르몬 결핍 및 이차 부신 부전의 평가를위한 테스트 펩티드로 판매되고 있습니다. GHRP-2는 짧은 키의 평가를위한 II 기 임상 시험에서 조사되었으며 식욕, 근육 성장, 면역계 및 수면주기에 미치는 영향에 대한 적극적인 연구 중입니다. GHRP-2는 구두로 및 설하로 활성화되므로 그 효과를 갖도록 주입 할 필요가 없습니다.

GHRP-2 구조

원천:Pubch

순서:d-ala-d-2nal-ala-trp-d-phe-lys
분자식 :기음45시간55N9영형6
분자량 :817.9749 g/mol
Pubchem CID : 6918245
CAS 번호 :158861-67-7
코드 이름 :KP-102, GPA-748, Way-GPA-748

GHRP-2 효과

1. 근육 구조를 보호하고 향상시킵니다

Yaks의 연구에 따르면 GHRP-2는 두 가지 방식으로 근육 성장을 촉진 할 수 있습니다 : 단백질 침착 증가 및 단백질 분해 감소. 연구에 따르면 GHRP-2는 식품 박탈, 질병 및 불리한 환경 조건으로 인해 야크에서 발생하는 자연 성장 고원을 극복 할 수 있습니다 (예 : 추위).[1]. The most profound finding from this study is that GHRP-2 reduces muscle atrophy by inactivating atrogin-1 and MuRF1, proteins that control the muscle degradation pathway[2]. There is hope that these findings could be used to reduce the catabolism common in chronic illnesses like autoimmune disease, cancer, and more.

Of course, by activating growth hormone and insulin-like growth factor-1, GHRP-2 helps to boost muscle protein deposition. The combined effect of reducing degradation and enhancing deposition is that GHRP-2 encourages the development of lean body mass even in adverse conditions[3].

2. Stimulates Appetite

GHRP-2 has been shown to boost food intake[4], [5]. Though this may not seem acutely important, appetite stimulation in the setting of chronic disease is an important part of overall health care. The ability to easily and reliably stimulate appetite could help doctors treat chronically ill patients and improve long-term outcomes.

Food intake in healthy adult men, placebo versus GHRP-2
Source: PubMed

3. May Protect the Heart

Research in fetal heart cell culture lines shows that GHRP-2 and its analogues (GHRP-1 and GHRP-6) can help to protect heart cells by reducing apoptosis or programmed cell death[6]. This is of particular importance following heart attack, when heart cells are particularly prone to apoptosis thanks to decreased blood and thus nutrient supply. Research using an analogue of GHRP-2 called Hexarelin has indicated that there may be a specific receptor for these peptides[7]. Identifying new receptors in any tissue opens pathways for new drug development, but also deepens our understanding of the human physiology and how to prevent dysfunction in the first place.

4. Improves the Immune System

GHRP-2 has been shown to stimulate the thymus, an organ responsible for protecting certain cells of the immune system. In particular., the thymus helps T cells to mature. T cells are critical for adaptive immunity and our ability to fight off complex infections. Function of the thymus declines with age, which leads to a number of age-related dysfunctions ranging from inadequate tissue repair to lost immunity and thus an inability to fight off infections, guard against cancer, and maintain normal tissue function. GHRP-2 has been shown to rejuvenate the thymus, boosting the number and diversity of T-cells it produces[8]. This leads to improved immunity.

Change in number of active T-cells following administration of GHRP-2
Source: PubMed

5. Improves Sleep Quality

GHRP-2 has been shown to increase the duration stages 3 and 4 of the sleep cycles by about 50% each while increasing REM sleep by approximately 20% while reducing the amount that an individual deviates from “normal sleep” by as much as a third. Overall, the improvement in sleep led to improvement in cognitive function, blood pressure, healing, and energy levels[9]. These findings, while useful to all adults, are particularly important in the elderly, where the effects of aging take a toll on sleep quality. GHRP-2 may be useful in understanding how to fine-tune sleep to improve quality and maybe even help people get all the benefits of a full night’s sleep in a fraction of the time.

6. May Affect Pain Perception

It was originally thought that observations of decreased pain in animal models of osteoarthritis were the result of GHRP-2 boosting growth hormone levels and accelerating healing in the damaged tissues. Keen scientists observed, however, that the pain relief preceded healing by a substantial margin, suggesting that GHRP-2 may have direct effects on pain perception. As it turns out, GHRP-2 has action at the opioid receptors[10].

There are four known opioid receptors. Most opioid pain medications do not discriminate between them. This is problematic because while some of the receptors mediate pain, others affect things like wakefulness and breathing while still others impact addiction. GHRP-2 is a selective opioid receptor agonist, binding primarily to the receptors responsible for pain relief, sedation, and addiction. This finding indicates that it may be possible to produce selective opioid agonists and therefore mitigate or prevent entirely undesirable effects like respiratory depression and addiction.

GHRP-2 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. GHRP-2 for sale at

Peptide Gurus is limited to educational and scientific research only, not for human consumption. Only buy GHRP-2 if you are a licensed researcher.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Scientific Journal Author

Jean-Alain Fehrentz was born in Nancy, France, in 1955. He received his Ph.D. degree in Chemistry from the University of Nancy in 1983 and joined the Centre CNRS-INSERM de Pharmacologie Endocrinologie of Montpellier in the research group of Professor B. Castro. From 1989 to 1992 he was appointed as researcher at Sanofi Research in Montpellier. Then he moved to the Faculty of Pharmacy of Montpellier, working under the direction of Professor J. Martinez. His research interests focus onpeptide aldehydes, enzyme inhibitors, peptidomimetics, growth hormone interactions, and heterocycle based receptor ligands. He has published more than 150 scientific papers.

Jean-Alain Fehrentz is being referenced as one of the leading scientists involved in the research and development of GHRP-2. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between

Peptide Gurus and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Jean-Alain Fehrentz is listed in [11] under the referenced citations.

Referenced Citations

  1. R. Hu et al., “Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation,” PloS One, vol. 11, no. 2, p. e0149461, 2016. [PLOS ONE]
  2. D. Yamamoto et al., “GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1,” Life Sci., vol. 82, no. 9–10, pp. 460–466, Feb. 2008. [PubMed]
  3. L. T. Phung et al., “The effects of growth hormone-releasing peptide-2 (GHRP-2) on the release of growth hormone and growth performance in swine,” Domest. Anim. Endocrinol., vol. 18, no. 3, pp. 279–291, Apr. 2000. [PubMed]
  4. B. Laferrère, C. Abraham, C. D. Russell, and C. Y. Bowers, “Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men,” J. Clin. Endocrinol. Metab., vol. 90, no. 2, pp. 611–614, Feb. 2005. [PubMed]
  5. B. Laferrère, A. B. Hart, and C. Y. Bowers, “Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake,” Obes. Silver Spring Md, vol. 14, no. 6, pp. 1056–1063, Jun. 2006. [PMC]
  6. G. Muccioli et al., “Growth hormone-releasing peptides and the cardiovascular system,” Ann. Endocrinol., vol. 61, no. 1, pp. 27–31, Feb. 2000. [PubMed]
  7. V. Bodart et al., “Identification and characterization of a new growth hormone-releasing peptide receptor in the heart,” Circ. Res., vol. 85, no. 9, pp. 796–802, Oct. 1999. [AHA Journals]
  8. D. D. Taub, W. J. Murphy, and D. L. Longo, “Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways,” Curr. Opin. Pharmacol., vol. 10, no. 4, pp. 408–424, Aug. 2010. [PubMed]
  9. G. Copinschi et al., “Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man,” Neuroendocrinology, vol. 66, no. 4, pp. 278–286, Oct. 1997. [PubMed]
  10. P. Zeng et al., “Ghrelin receptor agonist, GHRP-2, produces antinociceptive effects at the supraspinal level via the opioid receptor in mice,” Peptides, vol. 55, pp. 103–109, May 2014. [PubMed]
  11. Moulin, A. , Ryan, J. , Martinez, J. and Fehrentz, J. (2007), Recent Developments in Ghrelin Receptor Ligands. ChemMedChem, 2: 1242-1259. doi:10.1002/cmdc.200700015

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