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Rapporto di prova Pinealon 16mg
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Rapporto di prova Pinealon 16mg

Pinealon 16mg (bioregolatore)

Contatto per ordine

Pinealon 16mgè un peptide sintetico progettato per migliorare la funzione cerebrale, migliorare la memoria e proteggere dalle malattie neurodegenerative. È noto per le sue proprietà neuroprotettive e cognitive. Pinealon è spesso utilizzato per sostenere la salute del cervello, migliorare le capacità cognitive e contribuire a contrastare gli effetti dell'invecchiamento sul cervello.

Proprietà chiave e usi di Pinealon 16mg:

  1. Cognitive Enhancement:

    • Pinealon viene utilizzato principalmente per la sua capacità di migliorare le funzioni cognitive come memoria, apprendimento e concentrazione. È stato dimostrato di supportare la produzione di neurotrasmettitori chiave coinvolti nella memoria e nella chiarezza mentale, rendendo utile per migliorare le prestazioni mentali.
  2. Neuroprotection:

    • Uno dei benefici più significativi di Pinealon sono le sue proprietà neuroprotettive. Aiuta a proteggere i neuroni dallo stress ossidativo, che è una delle principali cause di malattie neurodegenerative come quella di Alzheimer e Parkinson. Questo peptide supporta la salute del cervello a lungo termine e può aiutare a ridurre il rischio di declino cognitivo.
  3. Anti-Aging Effects:

    • Pinealon è stato studiato per il suo potenziale per rallentare il processo di invecchiamento nel cervello. Promuovendo la riparazione e la rigenerazione cellulare, aiuta a mitigare gli effetti cognitivi dell'invecchiamento, mantenere la nitidezza mentale e prevenire la perdita di memoria legata all'età.
  4. Mood Regulation:

    • Oltre ai suoi benefici cognitivi, Pinealon ha anche dimostrato di supportare la regolazione dell'umore. Può aiutare a ridurre i sintomi di ansia e depressione modulando i neurotrasmettitori come la serotonina e la dopamina, che sono essenziali per il benessere emotivo.
  5. Recovery from Brain Injury:

    • Pinealon viene talvolta utilizzato nel processo di recupero dopo lesioni cerebrali traumatiche (TBI). Aiuta ad accelerare la guarigione dei tessuti cerebrali e migliorare la funzione cerebrale complessiva durante la fase di recupero.
  6. Enhances Synaptic Plasticity:

    • Pinealon funziona migliorando la plasticità sinaptica, che è essenziale per la capacità del cervello di adattarsi a nuovi apprendimenti ed esperienze. Ciò rende prezioso per le persone che desiderano aumentare la loro capacità di memoria e l'adattabilità al cervello.

Amministrazione e dosaggio:

  • Amministrazione: Pinealon 16mg viene generalmente somministrato tramite iniezione sottocutanea. Questo metodo garantisce che il peptide sia assorbito in modo efficiente nel flusso sanguigno per un'azione mirata sulle cellule cerebrali.

  • Dosaggio: Il dosaggio raccomandato di Pinealon è in genere 16 mg per iniezione, con la frequenza e la durata dell'uso che variano in base agli obiettivi individuali e alle esigenze di salute. È importante seguire la guida medica per un utilizzo adeguato, in particolare per coloro che lo usano per gestire il declino cognitivo o le condizioni neurodegenerative.

Considerazioni e avvertimenti:

  • Effetti collaterali: Pinealon è generalmente ben tollerato, ma alcuni individui possono sperimentare lievi effetti collaterali come mal di testa, vertigini o leggero disagio nel sito di iniezione. Questi sono in genere temporanei e si placano man mano che il corpo si adatta al peptide.

  • Supervisione medica: A causa degli effetti sulla funzione cerebrale, Pinealon dovrebbe essere utilizzato sotto la supervisione di un operatore sanitario, in particolare per le persone con condizioni neurologiche preesistenti o per quelli sottoposti a trattamenti cognitivi per la salute.

  • Stato normativo: Mentre Pinealon ha dimostrato promesse in vari studi, potrebbe non essere ampiamente approvato per l'uso clinico in tutte le regioni. È spesso commercializzato come peptide di ricerca e il suo uso dovrebbe rispettare le normative locali.

Riepilogo:

Pinealon 16mg offre un approccio mirato al miglioramento della funzione cognitiva, alla protezione dalle malattie neurodegenerative e al supporto alla salute generale del cervello. Le sue proprietà neuroprotettive e cognitive lo rendono prezioso sia per gli individui sani sia per coloro che si occupano di declino cognitivo legato all'età. Tuttavia, a causa dei suoi potenti effetti biologici, dovrebbe essere utilizzato con la supervisione medica.

Acqua batteriostatica libera (1) da 30 ml
con ordini qualificati$ 500 USD.
(Esclude prodotti capsule, peptidi cosmetici, codici promozionali e spedizione)

Pinealon è un peptide sintetico di soli tre aminoacidi. È stato dimostrato che modifica il comportamento e protegge un numero di tipi di cellule dagli effetti dell'ipossia. Ha subito una ricerca approfondita per la sua capacità di alterare il ritmo circadiano, migliorare la memoria e migliorare l'apprendimento. È stato dimostrato che compensa gli effetti dell'invecchiamento, in particolare nel sistema nervoso centrale, e può essere utile nel trattamento dei disturbi cognitivi come la malattia di Alzheimer.

Utilizzo del prodotto:Questo prodotto è inteso solo come chimica di ricerca.Questa designazione consente l'uso di sostanze chimiche di ricerca rigorosamente solo per test in vitro e sperimentazione di laboratorio. Tutte le informazioni sul prodotto disponibili su questo sito Web sono solo a scopo educativo. L'introduzione corporea di qualsiasi tipo nell'uomo o negli animali è severamente vietata dalla legge. Questo prodotto dovrebbe essere gestito solo da professionisti autorizzati e qualificati. Questo prodotto non è un farmaco, un cibo o un cosmetico e potrebbe non essere maltrattato, utilizzato in modo improprio o erroneamente come droga, cibo o cosmetici.

Cos'è Pinealon?

Pinealon è un peptide corto costituito da soli tre aminoacidi. È uno dei manciati di peptidi sintetici indicati come bioregolatori peptidici per la loro capacità di interagire direttamente con il DNA per alterare i livelli di espressione genica. Pinealon è stato collegato alla modifica del comportamento e si pensa che aiuti a proteggere un numero di tipi di cellule, compresi i neuroni, dagli effetti dell'ipossia. Per effetto diretto sulla ghiandola pineale, Pinealon può ridurre i problemi con il metabolismo dei farmaci, i disturbi del ritmo circadiano, la memoria, l'apprendimento e altro ancora.

Struttura di pinealon

Struttura di pinealonFonte:Pubch

Sequenza:Glu-Asp-Arg
Formula molecolare:C15H26N6O8
Peso molecolare:418.407 g/mol
Pubchem cid: 18220191
Sinonimi:Glutamilaspartilarginina, peptide T-33

Pinealon interagisce direttamente con il DNA

A differenza della maggior parte dei peptidi, Pinealon non sembra legarsi alla superficie cellulare o ai recettori citoplasmatici. Ciò ha portato gli scienziati a chiedersi come il peptide corto possa avere qualsiasi effetto. In passato, è stato suggerito che Pinealon potrebbe essere abbastanza piccolo da attraversare i doppi strati lipidici (ad esempio la membrana cellulare, la membrana nucleare) e potrebbe quindi essere in grado di interagire direttamente con il DNA. Il test nelle colture cellulari (cellule HeLa) indica che Pinealon penetra direttamente sulla membrana cellulare e la membrana nucleare per interagire con il DNA[1]. This makes pinealon a regulator of gene expression and explains the peptide’s myriad effects that cannot be explained by receptor interactions.

Pinealon Research

Pinealon Research and Aging

Pinealon may have anti-aging effects in the central nervous system. Research from Russia indicates that pinealon and a similar peptide, vesugen, are anabolic in the brain and can actually slow the rate of aging when calculated using biological age indicators[2].

Pinealon is active in cells outside of the central nervous system as well. Research shows that the peptide also has effects on muscle cells where it alters the expression of irisin[3]. Irisin is important to protecting muscle cells during exercise, promotes fat burning, and is thought to induce telomere elongation as well. By increasing the lifespan of irisin, pinealon boosts telomere protection and helps to fight off the effects of aging and oxidative stress. In fact, plasma irisin levels are directly linked to telomere length in healthy adults and levels of the enzyme have been directly linked to calorie restriction, one of the few activities known beyond doubt to prolong life and improve overall fitness[4]. Interestingly, there is evidence that irisin is active outside of muscle cells and that pinealon may therefore have anti-aging effects that are broadly distributed throughout the body, including the brain.

Pinealon Research and Neuron Protection

Research in prenatal rats indicates that pinealon protects neurons against oxidative stress and thus protects cognitive function and motor coordination[5]. The study showed marked decreases in both reactive oxygen species accumulation as well as number of necrotic cells in the brain in these rats. In other words, pinealon protects neurons from dying.

The findings of the prental rat study discussed above have been confirmed in separate studies and extended in others. Confirmation that pinealon protects against reactive oxygen species and reduces necrotic cell death also came with the understanding that the peptide modifies the cell cycle as part of its protection against cell death[6]. This was one of the first indications that pinealon was almost certainly interacting at the level of DNA. Interestingly, pinealon modulates the cell cycle by activating proliferation pathways. Under normal circumstances, this would lead to an increase in cell number, but under the setting of oxidative stress, this effect simply offsets some of the damaging effects of reactive oxygen species.

Measure of reactive oxygen species in controls, those exposed to ouabain, and animals exposed to both ouabain and pinealon at various doses.Measure of reactive oxygen species in controls, those exposed to ouabain, and animals exposed to both ouabain and pinealon at various doses.
Source: Semantic Scholar

Research in adult rats deprived of oxygen has also shown that pinealon increases the resistance of neurons to hypoxic stress. It appears to do this by stimulating innate anti-oxidative enzyme systems and limiting the excitotoxic effects of N-methyl-D-aspartate[7]. N-methyl-D-aspartate (NMDA) is an amino acid derivative that can kill nerve cells by over-exciting them. NMDA has been shown to become overactive during withdrawal from alcohol and is at least partly responsible for the “shakes” or delirium tremors that affects chronic alcoholics during withdrawal. NMDA has been linked to nerve death in traumatic brain injury and ischemic stroke.

Irisin, which has been discussed in the context of muscle cell protection, has recently been found in the brain where it plays important roles in neural differentiation, proliferation, and energy expenditure. Irisin levels in the central nervous system has been found to stimulate genes in the hippocampus that are important to memory, learning, the overall neuron health[8]. Research in rats suggests that exercise directly boosts levels of irisin in the brain, which may finally provide the link between physical activity and cognition. Scientists have speculated that irisin is the messenger that mediates crosstalk between skeletal muscle and the central nervous system during exercise. Pinealon boosts levels of irisin by altering expression of the gene that codes for the enzyme. This leads to increased levels of irisin through prolonged lifespan of the enzyme.

Pinealon research and Depression

Research in cultures of brain cortex cells indicate that pinealon can boost expression of 5-tryptophan hydroxylase via epigenetic changes. 5-tryptophan hydroxylase is critical to the production and secretion of serotonin, a peptide known to have neuroprotective and geroprotective features[9]. It is also the signaling molecule most often targeted by anti-depressive drugs called selective-serotonin reuptake inhibitors (SSRIs). SSRIs have a number of side effects, however, and the ability to boost serotonin production organically could offer a means of fighting depression that is more physiologic and thus reduce side effects.

Pinealon Protects Cells from Caspase-3 and Cell Death

The initial understanding that pinealon could affect the cell cycle came from research into the effects of the peptide in rat models of ischemic stroke. These studies revealed that pinealon affects cytokine signaling that normally leads to an increase in levels of the caspase-3 enzyme[10]. Caspase-3 is directly responsible for initiating apoptosis, or the controlled death of a cell via genetic instruction. By modulating caspase-3, pinealon shuts down at least one pathway to cell death and thus reduces the effects of oxygen deprivation during stroke.

Caspase-3 is not only active in neurologic tissue though, it is almost universal. Research using models of heart attack indicates that pinealon may reduce caspase-3 levels following myocardial infarction[11]. The short peptide may have application both in treating heart attack and in preventing the long-term remodeling that causes so much dysfunction following a myocardial infarction.

The benefit of pinealon in suppressing caspase-3 expression has been demonstrated in skin cells. By reducing apoptosis in the skin, pinealon promotes cell proliferation in both young and old animals alike. This leads to an increase in the regenerative process and has been shown to offset age-related pathology in the skin[12]. Pinealon may eventually form part of a multi-faceted approach to wound healing and could have application in everything from sun protection to serious burn treatment.

Pinealon Research and Sleep Regulation

It should come as no surprise, given its names, that pinealon affects that sleep-wake cycle as well as sleep behavior. Research indicates, that pinealon may help to regulate the dysfunction caused by shift-work and other activities (e.g. long-distance travel) that interfere with normal sleep patterns. The peptide actually appears to reset the pineal gland to baseline in the setting of circadian rhythm disruption, improving sleep, depression, mood, blood pressure, and more as a result[13].

The ability to regulate sleep actually corresponds strongly with rates of aging. Disturbed sleep is a recipe for disaster in the body and affects cognition, cardiac health, wound healing, mood, and more. Pinealon may therefore help to reduce the impact of sleep disturbance and thus offset the effects that it has on aging. This could be beneficial not only to those forced into disorder sleep due to their jobs, but to individuals suffering from organic disease that impacts sleep-wake cycles.

Pinealon exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Pinealon for sale at

Peptide Gurus is limited to educational and scientific research only, not for human consumption. Only buy Pinealon if you are a licensed researcher.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Scientific Journal Author

Vladimir Khavinson is a Professor, President of the European region of the International Association of Gerontology and Geriatrics; Member of the Russian and Ukrainian Academies of Medical Sciences; Main gerontologist of the Health Committee of the Government of Saint Petersburg, Russia; Director of the Saint Petersburg Institute of Bioregulation and Gerontology; Vice-president of Gerontological Society of the Russian Academy of Sciences; Head of the Chair of Gerontology and Geriatrics of the North-Western State Medical University, St-Petersburg; Colonel of medical service (USSR, Russia), retired. Vladimir Khavinson is known for the discovery, experimental and clinical studies of new classes of peptide bioregulators as well as for the development of bioregulating peptide therapy. He is engaged in studying of the role of peptides in regulation of the mechanisms of ageing. His main field of actions is design, pre-clinical and clinical studies of new peptide geroprotectors. A 40-year-long investigation resulted in a multitude of methods of application of peptide bioregulators to slow down the process of aging and increase human life span. Six peptide-based pharmaceuticals and 64 peptide food supplements have been introduced into clinical practice by V. Khavinson. He is an author of 196 patents (Russian and international) as well as of 775 scientific publications. His major achievements are presented in two books: “Peptides and Ageing” (NEL, 2002) and “Gerontological aspects of genome peptide regulation” (Karger AG, 2005). Vladimir Khavinson introduced scientific specialty “Gerontology and Geriatrics” in the Russian Federation on the governmental level. Academic Council headed by V. Khavinson has oversighted over 200 Ph.D. and Doctorate theses from many different countries.

Prof. Vladimir Khavinson is being referenced as one of the leading scientists involved in the research and development of Pinealon. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between

Peptide Gurus and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Prof. Vladimir Khavinson is listed in [1] [3] [5] [6] and [9] under the referenced citations.

 

The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.

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